![]() ![]() ![]() The pathophysiology of sepsis-associated DIC is multifactorial, and in addition to coagulation activation with suppressed fibrinolysis, multiple inflammatory responses are initiated by activated leukocytes, platelets, and vascular endothelial cells as part of thromboinflammation. Main bodyĭIC is a laboratory-based diagnosis due to various critical conditions, although sepsis is the most common underlying disease. Thus, the ISTH has recently released sepsis-induced coagulopathy (SIC) criteria that can diagnose compensated-phase of coagulopathy with readily available biomarkers. However, DIC is not merely a decompensated coagulation disorder, but also includes early stages with systemic activation in coagulation. Since then, DIC has been understood as the end-stage consumptive coagulopathy and not the therapeutic target. The International Society on Thrombosis and Haemostasis (ISTH) released overt disseminated intravascular coagulation (DIC) diagnostic criteria in 2001. ![]()
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